Introduction

Here, I offer a rapid overview of the theory of metaphor, in order to situate the contributions to this volume in relation to one another and within the field more generally

Showing, Telling and Seeing. Metaphor and “Poetic” Language

Theorists often associate certain “poetic” qualities with metaphor – most especially, producing an open-ended, holistic perspective which is evocative, imagistic and affectively-laden. I argue that, on the one hand, non-cognitivists are wrong to claim that metaphors only produce such perspectives: like ordinary literal speech, they also serve to undertake claims and other speech acts with propositional content. On the other hand, contextualists are wrong to assimilate metaphor to literal loose talk: metaphors depend on using one thing as a perspective for thinking about something else. I bring out the distinctive way that metaphor works by contrasting it with two other poetic uses of language, juxtapositions and “telling details,” that do fit the accounts of metaphor offered by non-cognitivists and contextualists, respectively

Different Neutralization Profiles After Primary SARS-CoV-2 Omicron BA.1 and BA.2 Infections

Background and MethodsThe SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) Omicron (B.1.1.529) variant is the antigenically most distinct variant to date. As the heavily mutated spike protein enables neutralization escape, we studied serum-neutralizing activities of naïve and vaccinated individuals after Omicron BA.1 or BA.2 sub-lineage infections in live virus neutralization tests with Omicron BA.1, Omicron BA.2, wildtype (WT, B1.1), and Delta (B.1.617.2) strains. Serum samples obtained after WT infections and three-dose mRNA vaccinations with and without prior infection were included as controls.ResultsPrimary BA.1 infections yielded reduced neutralizing antibody levels against WT, Delta, and Omicron BA.2, while samples from BA.2-infected individuals showed almost no cross-neutralization against the other variants. Serum neutralization of Omicron BA.1 and BA.2 variants was detectable after three-dose mRNA vaccinations, but with reduced titers. Vaccination-breakthrough infections with either Omicron BA.1 or BA.2, however, generated equal cross-neutralizing antibody levels against all SARS-CoV-2 variants tested.ConclusionsOur study demonstrates that although Omicron variants are able to enhance cross-neutralizing antibody levels in pre-immune individuals, primary infections with BA.1 or BA.2 induced mostly variant-specific neutralizing antibodies, emphasizing the differently shaped humoral immunity induced by the two Omicron variants. These data thus contribute substantially to the understanding of antibody responses induced by primary Omicron infections or multiple exposures to different SARS-CoV-2 variants and are of particular importance for developing vaccination strategies in the light of future emerging variants

Showing, telling and seeing: Metaphor and ‘poetic’ language

ABSTRACT: Theorists often associate certain “poetic ” qualities with metaphor – most especially, producing an open-ended, holistic perspective which is evocative, imagistic and affectively-laden. I argue that, on the one hand, non-cognitivists are wrong to claim that metaphors only produce such perspectives: like ordinary literal speech, they also serve to undertake claims and other speech acts with propositional content. On the other hand, contextualists are wrong to assimilate metaphor to literal loose talk: metaphors depend on using one thing as a perspective for thinking about something else. I bring out the distinctive way that metaphor works by contrasting it with two other poetic uses of language, juxtapositions and “telling details, ” that do fit the accounts of metaphor offered by non-cognitivists and contextualists, respectively. Consider the following literary metaphors

Introduction

Here, I offer a rapid overview of the theory of metaphor, in order to situate the contributions to this volume in relation to one another and within the field more generally